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Ranitidine base CAS 6131-90-4
Details of ranitidine base
Ranitidine Base is a powerful histamine-2 receptor antagonist that works by reducing the amount of acid produced in the stomach. It is commonly used to treat various gastrointestinal disorders such as gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome. Ranitidine Base has a long history of safe and effective use, with numerous clinical studies demonstrating its efficacy in the management of acid-related disorders.
CAS:6131-90-4
Chemical Name: N-[2-[[5-[(Dimethylamino)methyl]-2-furanylmethyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (Anhydrous)
Classification: Organic base
Molecule: C13H22N4O3S
Molecule Weight: 314.41
Structural Formula:
Quality Standard: Q/82HL03-2004
Parameter of ranitidine base
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| Characteristics | White or almost white powder |
| Assay (HPLC) | 97.5%~102.0% |
| Any impurity | not more than 0.2% |
| Moisture (K.F method) | not more than 0.5% |
| Package | 25kg/bag |
| Application | Intermediate of Ranitidine |
Ranitidine Base Features and Benefits:
1.High Solubility: Ranitidine Base is highly soluble in water and ethanol, making it easy to formulate into various oral dosage forms such as tablets, capsules, and syrups.
2.Potent Acid Reducer: Ranitidine Base is a potent acid reducer that can effectively control acid production in the stomach, providing relief from acid-related disorders.
3.Proven Efficacy: Ranitidine Base has a long history of safe and effective use, with numerous clinical studies demonstrating its efficacy in the management of acid-related disorders.
4.Cost-Effective: Ranitidine Base is a cost-effective alternative to other acid-reducing medications, making it an ideal choice for patients who require long-term treatment.
Methods of Manufacturing
5-[(Dimethylamino)methyl]-2-furanmethanol (I) reacts with cysteine to form 2-[[5-[(dimethylamino)methyl-2-furyl]methyl] Thio]ethylamine (II). 230g of N-methyl-1-methylthio-2-nitroethylene methylamine was dissolved in 400ml of water, heated and stirred at 45-50°C, 321g of compound (II) was added dropwise within 4h, and stirring was continued for 3.5h after the addition. Then reflux for another 0.5h and cool to. At 70°C, add 2L of 4-methyl-2-pentanone. The water was azeotropically distilled under reduced pressure (34.7kPa), and then reacted with 10g activated carbon at 50°C. After removing the activated carbon by filtration, cool to 10°C, filter the precipitated ranitidine, and dry it to obtain about 380g, with a melting point of 69-70°C.
Uses of ranitidine base
Long-acting and potent H2 receptor antagonist can effectively inhibit gastric acid secretion caused by histamine, pentagastrin and food stimulation, reduce the basic regular gastric acid and inhibit the activity of gastric enzymes. Its intensity of action is 5-8 times that of cimetidine. This product is suitable for benign gastric and duodenal ulcers, postoperative ulcers, reflux esophagitis and Zhuo-Ehrlid~"s syndrome.
Applications:
Ranitidine Base can be used in the formulation of various oral dosage forms, including tablets, capsules, and syrups. It can also be used in combination with other active ingredients to create multi-component formulations that provide enhanced therapeutic effects.
Synonyms
- Ranitidine HCL
- Ranitidine hydrochloride
- Rantidine HCL
- Ranitidin AL
- Ranitidin AWD
- Ranitidin Arcana
- Ranitidin Atid
- Ranitidin Basics
- Ranitidin Duncan
- Ranitidin Dyna
- Ranitidin Helvepharm
- Ranitidin Heumann
- Ranitidin Hexal
- Ranitidin Merck
- Ranitidin Millet
- Ranitidin NM
- Ranitidin Normon
- Ranitidin PB
- Ranitidin Stada
- Ranitidin von ct
- Ranitidin-Cophar
- Ranitidin-Isis
- Ranitidin-ratiopharm
- Ranitidina Tamarang
- Ranitidina predilu Grif
Ranitidine Base is a powerful histamine-2 blocker that offers numerous benefits to pharmaceutical companies looking to develop new oral dosage forms. Its high solubility, proven efficacy, and cost-effectiveness make it an ideal choice for the treatment of various gastrointestinal disorders. Our company is committed to providing high-quality and cost-effective products to our customers, and we are confident that Ranitidine Base will meet the needs of pharmaceutical companies looking to develop new treatments for acid-related disorders.
If you want to get more information about ranitidine base, please feel free to contact us.
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Hebei Hailihengyuan New Material Co., LTD. was established in December 2003, covering an area of 26700m², with a registered capital of 40.2 million, 281 employees and a sales volume of 198 million in 2019.
The company specializes in the development, production and sales of chemical APIs, spices, polyimide monomers.
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