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Ranitidine base

Welcome to contact Haili for more details about ranitidine base.
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Details of ranitidine base

 

CAS:6131-90-4

Chemical Name: N-[2-[[5-[(Dimethylamino)methyl]-2-furanylmethyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (Anhydrous)

Classification: Organic base

Molecule: C13H22N4O3S

Molecule Weight: 314.41

Structural Formula:

Quality Standard: Q/82HL03-2004

 

 If you are looking ranitidine base supplier in China, welcome to contact us.

 

 

Parameter of ranitidine base

 

ITEM
INDEX
Characteristics White or almost white powder
Assay (HPLC) 97.5%~102.0%
Any impurity not more than 0.2%
Moisture (K.F method) not more than 0.5%
Package 25kg/bag
Application Intermediate of Ranitidine

 

Methods of Manufacturing

 

5-[(Dimethylamino)methyl]-2-furanmethanol (I) reacts with cysteine to form 2-[[5-[(dimethylamino)methyl-2-furyl]methyl] Thio]ethylamine (II). 230g of N-methyl-1-methylthio-2-nitroethylene methylamine was dissolved in 400ml of water, heated and stirred at 45-50°C, 321g of compound (II) was added dropwise within 4h, and stirring was continued for 3.5h after the addition. Then reflux for another 0.5h and cool to. At 70°C, add 2L of 4-methyl-2-pentanone. The water was azeotropically distilled under reduced pressure (34.7kPa), and then reacted with 10g activated carbon at 50°C. After removing the activated carbon by filtration, cool to 10°C, filter the precipitated ranitidine, and dry it to obtain about 380g, with a melting point of 69-70°C.

 

Uses of ranitidine base

 

Long-acting and potent H2 receptor antagonist can effectively inhibit gastric acid secretion caused by histamine, pentagastrin and food stimulation, reduce the basic regular gastric acid and inhibit the activity of gastric enzymes. Its intensity of action is 5-8 times that of cimetidine. This product is suitable for benign gastric and duodenal ulcers, postoperative ulcers, reflux esophagitis and Zhuo-Ehrlid~"s syndrome.

 

 

Synonyms

  • Ranitidine HCL
  • Ranitidine hydrochloride
  • Rantidine HCL
  • Ranitidin AL
  • Ranitidin AWD
  • Ranitidin Arcana
  • Ranitidin Atid
  • Ranitidin Basics
  • Ranitidin Duncan
  • Ranitidin Dyna
  • Ranitidin Helvepharm
  • Ranitidin Heumann
  • Ranitidin Hexal
  • Ranitidin Merck
  • Ranitidin Millet
  • Ranitidin NM
  • Ranitidin Normon
  • Ranitidin PB
  • Ranitidin Stada
  • Ranitidin von ct
  • Ranitidin-Cophar
  • Ranitidin-Isis
  • Ranitidin-ratiopharm
  • Ranitidina Tamarang
  • Ranitidina predilu Grif

 

If you want to get more information about ranitidine base, please feel free to contact us.

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Hebei Haili fragrances Co., Ltd. was established in December 2003, covering an area of 26700m², with a registered capital of 40.2 million, 281 employees and a sales volume of 198 million in 2019.
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